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Home / Primary Antibodies / Polyclonal Antibodies

PHF2 antibody

SKU : BHA10806376

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Mfr.No.	FNab06384
Alternative Names	CENP-35 ; KIAA0662
Background	Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3(H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3(H3K4me3) at rDNA promoters and promotes expression of rDNA.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA.
Host	Rabbit
Immunogen	PHD finger protein 2
Isotype	IgG
Molecular Weight	100 kDa, 150 kDa
Reactivity	Human
Regulatory	RUO
Synonyms	GRC5, JHDM1E, KIAA0662, PHD finger protein 2, PHF2

Uniprot	O75151
Gene Id	5253
Research Area	Epigenetics, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IP
Description	ELISA ; WB ; IHC ; IP
Tested Application	WB: 1:200-1:1000; IP: 1:500-1:1000; IHC: 1:20-1:200

Manual	FNab06384.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10806376	FNab06384	100ug	$280		Add to Cart

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