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Home / Primary Antibodies / Polyclonal Antibodies

PDK1 antibody

SKU : BHA10806267

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Mfr.No.	FNab06275
Alternative Names	PDHK1
Background	Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
Host	Rabbit
Immunogen	pyruvate dehydrogenase kinase, isozyme 1
Isotype	IgG
Molecular Weight	50kd
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	PDH kinase 1, PDHK1, PDK1, Pyruvate dehydrogenase kinase isoform 1

Uniprot	Q15118
Gene Id	5163
Research Area	Signal Transduction, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC, WB, IP
Description	ELISA ; IHC ; WB ; IP
Tested Application	WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:50-1:500

Manual	FNab06275.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10806267	FNab06275	100ug	$260		Add to Cart

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