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Home / Primary Antibodies / Monoclonal Antibodies

PD-L1/CD274 antibody

SKU : BHA10806273

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Mfr.No.	FNab06281
Alternative Names	B7H ; B7H1 ; B7homolog1 ; B7H1 ; CD274 ; CD274molecule ; PDL1 ; PDCD1ligand1 ; PDCD1L1 ; PDCD1LG1 ; PDL1
Background	Programmed cell death ligand 1(CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa, the apparent molecular weight has been reported as 45-70 kDa, suggesting probable glycosylation(PMID: 18760278; 16493058).
Categories	Primary Antibodies
Clonality	monoclonal
Description	Programmed cell death ligand 1(CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa, the apparent molecular weight has been reported as 45-70 kDa, suggesting probable glycosylation (PMID: 18760278; 16493058).?
Host	Mouse
Immunogen	CD274 molecule
Isotype	IgG1
Reactivity	Human, Mouse, Pig
Regulatory	RUO
Synonyms	B7 H, B7 H1, B7 homolog 1, B7H1, CD274, CD274 molecule, PD L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, PD-L1, PD-L1/CD274, Programmed death ligand 1

Uniprot	Q9NZQ7
Clone No	6C11
Research Area	Cancer, Immunology, Signal Transduction
Weight	33kDa,observed 50kDa

Form	liquid
Format	liquid
Purification	Protein A+G purification
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF

Dilution

WB	1:500-1:5000
IHC	1:100-1:500
IF	1:50-1:500

Tested Application

WB: 1:500-1:5000; IHC: 1:100-1:500; IF: 1:50-1:500

Manual	FNab06281.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10806273	FNab06281	100ug	$280		Add to Cart

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