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Home / Primary Antibodies / Polyclonal Antibodies

PCNA antibody

SKU : BHA10806207

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Mfr.No.	FNab06215
Alternative Names	Proliferatingcellnuclearantigen，Cyclin
Background	The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Proliferating Cell Nuclear Antigen, commonly known as PCNA, is a protein that acts as a processivity factor for DNA polymerase δ in eukaryotic cells. This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. PCNA induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. It has to be loaded onto DNA in order to be able to stimulate APEX2. PCNA protein is highly conserved during evolution; the deduced amino acid sequences of rat and human differ by only 4 of 261 amino acids. PCNA has been used as loading control for proliferating cells. This antibody is a rabbit polyclonal antibody raised against an internal region of human PCNA.
Host	Rabbit
Immunogen	proliferating cell nuclear antigen
Isotype	IgG
Molecular Weight	38 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	Proliferating cell nuclear antigen, Cyclin

Uniprot	P12004
Gene Id	5111
Research Area	Epigenetics, Cell Division and Proliferation, Metabolism, Immunology, Cancer
Weight	38kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IF, IP, WB, IHC, FC

Description

ELISA ; IF ; IP ; WB ; IHC ; FC

Dilution

WB	1:1000-1:10000

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab06215.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10806207	FNab06215	100ug	$240		Add to Cart

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