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Home / Primary Antibodies / Polyclonal Antibodies

PABPC4 antibody

SKU : BHA10806090

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Mfr.No.	FNab06098
Alternative Names	APP1 ; PABP4
Background	Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).
Host	Rabbit
Immunogen	poly(A) binding protein, cytoplasmic 4 (inducible form)
Isotype	IgG
Molecular Weight	79 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	APP1, PABP4

Uniprot	Q13310
Gene Id	8761
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IF, IP
Description	ELISA ; WB ; IHC ; IF ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:10 - 1:100

Manual	FNab06098.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10806090	FNab06098	100ug	$240		Add to Cart

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