This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
Categories
Primary Antibodies
Clonality
polyclonal
Host
Rabbit
Immunogen
sequestosome 1
Isotype
IgG
Molecular Weight
62 kDa
Reactivity
Human
Regulatory
RUO
Synonyms
P62, sequestosome 1, SQSTM1, Ubiquitin binding protein p62
Uniprot
Q13501
Gene Id
8878
Research Area
Cardiovascular, Metabolism, Signal Transduction, Neuroscience
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)