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Home / Primary Antibodies / Polyclonal Antibodies

P21;CDKN1A antibody

SKU : BHA10806059

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Mfr.No.	FNab06067
Alternative Names	CAP20 ; CDKinteractingprotein1 ; CDKN1 ; CDKN1A ; CIP1 ; MDA6 ; MDA6 ; P21 ; p21CIP1 ; PIC1 ; SDI1
Background	CDKN1A(p21, CIP1, WAF1) is a cyclin-dependent kinase inhibitor. CDKN1A binds to and inhibits the activity of cyclin-CDK2 or-CDK4 complexes, and thus functions as a regulator of cell cycle progression at the G1 phase. The expression of CDKN1A is induced by wild-type but not mutant p53 protein, through which CDKN1A mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. CDKN1A can interact with proliferating cell nuclear antigen(PCNA), and plays a regulatory role in S phase DNA replication and DNA damage repair. CDKN1A was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.
Categories	Primary Antibodies
Clonality	polyclonal
Description	CDKN1A (p21, CIP1, WAF1) is a cyclin-dependent kinase inhibitor. CDKN1A binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at the G1 phase. The expression of CDKN1A is induced by wild-type but not mutant p53 protein, through which CDKN1A mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. CDKN1A can interact with proliferating cell nuclear antigen (PCNA), and plays a regulatory role in S phase DNA replication and DNA damage repair. CDKN1A was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.
Host	Rabbit
Immunogen	cyclin-dependent kinase inhibitor 1A(p21, Cip1)
Isotype	IgG
Molecular Weight	21 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	CAP20, CDK interacting protein 1, CDKN1, CDKN1A, CIP1, MDA 6, MDA6, P21, p21CIP1, PIC1, SDI1, WAF1

Uniprot	P38936
Gene Id	1026
Research Area	Cell Division and Proliferation, Metabolism, Immunology, Cancer
Weight	21kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IHC, IF, WB

Description

ELISA ; IHC ; IF ; WB

Dilution

WB	1:500-1:5000
IP	1:200-1:1000
IHC	1:50-1:500
IF	1:20-1:200

Tested Application

WB: 1:200-1:1000; IHC: 1:20-1:200

Manual	FNab06067.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10806059	FNab06067	100ug	$240		Add to Cart

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