Osteopontin(OPN), also known as SPP1, is a secreted glycophosphoprotein that belongs to the small integrin-binding ligand N-linked glycoprotein(SIBLING) family. Originally isolated from bone, OPN has been found in kidney, vascular tissues, biological fluids, and various tumor tissues(PMID: 15138464; 16406521). OPN can interact with CD44 and integrins and regulate diverse biological processes. It has a multifaceted role in bone development and remodeling, and is also involved in the inflammatory and immune response, oncogenesis and cancer progression.
Categories
Primary Antibodies
Clonality
polyclonal
Host
Rabbit
Immunogen
secreted phosphoprotein 1
Isotype
IgG
Molecular Weight
66 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
BNSP, Bone sialoprotein 1, BSPI, ETA 1, Nephropontin, OPN, Osteopontin, secreted phosphoprotein 1, SPP 1, SPP1, Urinary stone protein, Uropontin