Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate(PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P(PubMed:23934110)(Probable). Plays a role in negative regulation of lipid biosynthesis(PubMed:19554302). Negatively regulates APOB secretion from hepatocytes(PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids(PubMed:22906437). Also binds 25-hydroxycholesterol(PubMed:17428193). Binds phosphatidylserine(PubMed:23934110).
Categories
Primary Antibodies
Clonality
polyclonal
Description
Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (PubMed:23934110) (Probable). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110).
Host
Rabbit
Immunogen
oxysterol binding protein-like 10
Isotype
IgG
Molecular Weight
75-80kd,64kd
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
ORP10, OSBP9
Uniprot
Q9BXB5
Gene Id
114884
Research Area
Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)