This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5.
Categories
Primary Antibodies
Clonality
polyclonal
Host
Rabbit
Immunogen
occludin
Isotype
IgG
Molecular Weight
59 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
occludin, OCLN
Uniprot
Q16625
Gene Id
4950
Research Area
cardiovascular, Signal Transduction, Metabolism, Cancer, Neuroscience
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)