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Home / Primary Antibodies / Polyclonal Antibodies

OAS1 antibody

SKU : BHA10810582

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Mfr.No.	FNab10795
Background	Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates(2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L(RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus(VSV), herpes simplex virus type 2(HSV-2), and encephalomyocarditis virus(EMCV) and stimulates the alternative antiviral pathway independent of RNase L.
Clonality	polyclonal
Host	Rabbit
Immunogen	2',5'-oligoadenylate synthetase 1, 40/46kDa
Immunogen Region	transducin-like enhancer of split 1
Isotype	IgG
Molecular Weight	48 kDa
Reactivity	Human, Rat
Recommended Dilution	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Synonyms	OIAS

Uniprot	P00973
Gene Id	4938
Research Area	Metabolism, Immunology

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:500-1:2000

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10855.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10810582	FNab10795	100ug	$240		Add to Cart

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