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Home / Primary Antibodies / Monoclonal Antibodies

NR1H3 antibody

SKU : BHA10805828

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Mfr.No.	FNab05836
Alternative Names	LXRA
Background	Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism(By similarity). Exhibits a ligand-dependent transcriptional activation activity(PubMed:25661920).
Categories	Primary Antibodies
Clonality	monoclonal
Description	Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half- sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920).
Host	Mouse
Immunogen	nuclear receptor subfamily 1, group H, member 3
Isotype	IgG2a
Molecular Weight	48 kDa
Reactivity	Human, Rat
Regulatory	RUO
Synonyms	Liver X receptor alpha, LXR a, LXRA, NR1H3, Oxysterols receptor LXR alpha, RLD 1

Uniprot	Q13133
Gene Id	10062
Clone No	7D2
Research Area	Cardiovascular, Metabolism, Signal Transduction, Neuroscience

Form	liquid
Format	liquid
Purification	Protein A+G purification
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IF
Description	ELISA ; WB ; IF
Tested Application	WB: 1:200-1:1000; IF: 1:10-1:100

Manual	FNab05836.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10805828	FNab05836	100ug	$280		Add to Cart

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