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Home / Primary Antibodies / Polyclonal Antibodies

NPC2 antibody

SKU : BHA10805805

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Mfr.No.	FNab05813
Alternative Names	HE1
Background	This gene encodes a protein containing a lipid recognition domain. The encoded protein may function in regulating the transport of cholesterol through the late endosomal/lysosomal system. Mutations in this gene have been associated with Niemann-Pick disease, type C2 and frontal lobe atrophy.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.
Host	Rabbit
Immunogen	Niemann-Pick disease, type C2
Isotype	IgG
Molecular Weight	16 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	HE1, Niemann Pick disease, type C2, NPC2

Uniprot	P61916
Gene Id	10577
Research Area	Cardiovascular, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab05813.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10805805	FNab05813	100ug	$260		Add to Cart

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