nNOS belongs to the NOS family. NOS1 produces nitric oxide(NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. NO is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. NO is synthesized from L-arginine by nitric oxide synthases. NOS1 is a nitric oxide synthase which is highly expressed in skeletal muscle. Genetic variations in NOS1 gene are associated with susceptibility to infantile hypertrophic pyloric stenosis type 1(IHPS1).The antibody can recognize isoform 1,2,4,5 of NOS1.
Categories
Primary Antibodies
Clonality
polyclonal
Host
Rabbit
Immunogen
nitric oxide synthase 1(neuronal)
Isotype
IgG
Molecular Weight
161kd
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
bNOS, Constitutive NOS, IHPS1, N NOS, NC NOS, Neuronal NOS, Nitric oxide synthase, brain, nNOS, NOS, NOS type I, NOS1
Uniprot
P29475
Research Area
Signal Transduction, Metabolism, Neuroscience
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)