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Home / Primary Antibodies / Polyclonal Antibodies

NGEF antibody

SKU : BHA10805712

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Mfr.No.	FNab05720
Background	Acts as a guanine nucleotide exchange factor(GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1-and CDC42-stimulated growth cone extension(By similarity).
Categories	Primary Antibodies
Clonality	polyclonal
Description	Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
Host	Rabbit
Immunogen	neuronal guanine nucleotide exchange factor
Isotype	IgG
Molecular Weight	75 kDa
Reactivity	Human, Mouse
Regulatory	RUO

Uniprot	Q8N5V2
Gene Id	25791
Research Area	Developmental biology

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IP
Description	ELISA ; WB ; IP
Tested Application	WB: 1:500-1:1000; IP: 1:500-1:1000; IHC: 1:50-1:500

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SKU	Supplier No.	Size	Your price	Quantity
BHA10805712	FNab05720	100ug	$260		Add to Cart

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