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Home / Primary Antibodies / Polyclonal Antibodies

NFKB1 antibody

SKU : BHA10810289

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Mfr.No.	FNab10334
Background	This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.
Clonality	polyclonal
Host	Rabbit
Immunogen	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Immunogen Region	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Isotype	IgG
Molecular Weight	50 kDa,105 kDa
Reactivity	Human, Mouse, Rat
Recommended Dilution	WB: 1:200-1:2000; IHC: 1:50-1:500
Synonyms	DNA binding factor KBF1, EBP 1, KBF1, NF kappa B, NFKB p105, NFKB p50, NFKB1, NFKB1,p105, NFKB1,p105,p50, nfkb1a, p105, p50

Uniprot	P19838
Gene Id	4790
Research Area	Epigenetics, Developmental biology, Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Neuroscience

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:200-1:2000; IHC: 1:50-1:500

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10334.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10810289	FNab10334	100ug	$240		Add to Cart

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