Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids(ESR1 and ESR2) independently of the steroid binding domain(AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors(ER) as well as the corepression of MYC in response to 17-beta-estradiol(E2).
Categories
Primary Antibodies
Clonality
polyclonal
Description
Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).
Host
Rabbit
Immunogen
nuclear receptor coactivator 5
Isotype
IgG
Molecular Weight
66 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
KIAA1637
Antigen
NCOA5
Uniprot
Q9HCD5
Gene Id
57727
Research Area
Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)