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Home / Primary Antibodies / Polyclonal Antibodies

NCK2 antibody

SKU : BHA10805576

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Mfr.No.	FNab05584
Alternative Names	GRB4
Background	This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling.
Host	Rabbit
Immunogen	NCK adaptor protein 2
Isotype	IgG
Molecular Weight	43 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	GRB4

Uniprot	O43639
Gene Id	8440
Research Area	Developmental biology, Signal Transduction

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab05584.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10805576	FNab05584	100ug	$240		Add to Cart

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