NAGA belongs to the glycosyl hydrolase 27 family. It removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. It is required for the breakdown of glycolipids. Biosynthetic studies performed with cultured fibroblasts indicated that the human enzyme was synthesized as a 65kDa glycosylated precursor which was processed to a mature 48-kDa lysosomal form; both the precursor and mature forms had high mannose type oligosaccharide chains, but only the precursor s mannose residues were phosphorylated. 90-117kd is a homodimer of NAGA.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids.
Host
Rabbit
Immunogen
N-acetylgalactosaminidase, alpha-
Isotype
IgG
Molecular Weight
48 kDa, 60-70 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
Alpha galactosidase B, D22S674, GALB, NAGA
Uniprot
P17050
Gene Id
4668
Research Area
Signal Transduction, Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)