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Home / Primary Antibodies / Polyclonal Antibodies

MYH10 antibody

SKU : BHA10805463

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Mfr.No.	FNab05471
Background	This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9.
Host	Rabbit
Immunogen	myosin, heavy chain 10, non-muscle
Isotype	IgG
Molecular Weight	250 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	NMMHC-IIB

Uniprot	P35580
Gene Id	4628
Research Area	Developmental biology, Cancer, Immunology

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IF, IP
Description	ELISA ; WB ; IF ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab05471.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10805463	FNab05471	100ug	$240		Add to Cart

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