This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.
Categories
Primary Antibodies
Clonality
polyclonal
Host
Rabbit
Immunogen
major vault protein
Isotype
IgG
Molecular Weight
100 kDa
Reactivity
Human, Mouse
Regulatory
RUO
Synonyms
LRP, major vault protein, MVP, VAULT1
Uniprot
Q14764
Gene Id
9961
Research Area
Cancer, Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)