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Home / Primary Antibodies / Polyclonal Antibodies

MTOR antibody

SKU : BHA10805409

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Mfr.No.	FNab05417
Alternative Names	FRAP ; FRAP1 ; FRAP2 ; RAFT1 ; RAPT1
Background	The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.
Categories	Primary Antibodies
Clonality	polyclonal
Description	MTOR, also named as FRAP1, FRAP, FRAP2 and RAPT1, belongs to the PI3/PI4-kinase family. MTOR is a Ser/Thr protein kinase that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth. MTOR is Kinase subunit of both mTORC1 and mTORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. The antibody is specific to MTOR.
Host	Rabbit
Immunogen	FK506 binding protein 12-rapamycin associated protein 1
Isotype	IgG
Molecular Weight	290 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	FRAP, FRAP1, FRAP2, RAFT1, RAPT1

Uniprot	P42345
Gene Id	2475
Research Area	Developmental biology, Cell Division and Proliferation, Signal Transduction, Metabolism, Cardiovascular, Immunology
Weight	289kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IP

Description

ELISA ; WB ; IHC ; IP

Dilution

WB	1:200-1:2000
IP	1:200-1:2000
IHC	1:20-1:200
IF	1:20-1:200

Tested Application

WB: 1:200 - 1:500; IHC: 1:100 - 1:200

Manual	FNab05417.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10805409	FNab05417	100ug	$240		Add to Cart

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