Modulator of melanocortin receptor 4(MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP(By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin(ACTH) to MC2R. May also regulate activity of other melanocortin receptors(MC1R, MC3R and MC5R); however, additional evidences are required in vivo.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.
Host
Rabbit
Immunogen
melanocortin 2 receptor accessory protein 2
Isotype
IgG
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
C6orf117
Uniprot
Q96G30
Gene Id
112609
Research Area
Signal Transduction, Immunology, Neuroscience
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)