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Home / Primary Antibodies / Polyclonal Antibodies

MMP14 antibody

SKU : BHA10805228

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Mfr.No.	FNab05236
Background	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro- MMP2.
Host	Rabbit
Immunogen	matrix metallopeptidase 14 (membrane-inserted)
Isotype	IgG
Molecular Weight	65 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	MMP-14

Uniprot	P50281
Gene Id	4323
Research Area	Cancer, Cardiovascular, Metabolism, Signal Transduction

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IF
Description	ELISA ; WB ; IF
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

Manual	FNab05236.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10805228	FNab05236	100ug	$240		Add to Cart

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