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Home / Primary Antibodies / Polyclonal Antibodies

MMP12 antibody

SKU : BHA10805226

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Mfr.No.	FNab05234
Alternative Names	HME
Background	MMP12(Matrix metalloproteinase-12) is a 54 kDa proenzyme that is processed into a 45 kDa and then a 22 kDa active form(15723202). MMP9 and MMP12 promote intimal thickening by independent cleavage of N-cadherin, which elevates vascular smooth muscle cell proliferation via beta-catenin signalling. Its overexpression in myeloid lineage cells plays a key role in modulating myelopoiesis, immune suppression, and lung tumorigenesis(PMID: 21378275).
Categories	Primary Antibodies
Clonality	polyclonal
Description	May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
Host	Rabbit
Immunogen	matrix metallopeptidase 12(macrophage elastase)
Isotype	IgG
Molecular Weight	54 kDa, 45 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	HME, Macrophage elastase, Macrophage metalloelastase, Matrix metalloproteinase 12, ME, MME, MMP 12, MMP12

Uniprot	P39900
Gene Id	4321
Research Area	Cardiovascular, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC
Description	ELISA ; WB ; IHC
Tested Application	WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100

Manual	FNab05234.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10805226	FNab05234	100ug	$280		Add to Cart

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