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Home / Primary Antibodies / Polyclonal Antibodies

MICAL2 antibody

SKU : BHA10805170

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Mfr.No.	FNab05178
Alternative Names	KIAA0750 ; MICAL2PV1 ; MICAL2PV2
Background	Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine- sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.
Host	Rabbit
Immunogen	microtubule associated monoxygenase, calponin and LIM domain containing 2
Isotype	IgG
Molecular Weight	95, 112 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	KIAA0750, MICAL2PV1, MICAL2PV2

Uniprot	O94851
Gene Id	9645
Research Area	Developmental biology, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC, IF
Description	ELISA ; IHC ; IF
Tested Application	IHC: 1:20-1:200; IF: 1:20-1:200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10805170	FNab05178	100ug	$260		Add to Cart

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