This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
Host
Rabbit
Immunogen
matrix Gla protein
Isotype
IgG
Molecular Weight
12 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
GIG36, matrix Gla protein, MGLAP, MGP, NTI
Uniprot
P08493
Gene Id
4256
Research Area
Developmental biology, Signal Transduction
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)