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Home / Primary Antibodies / Polyclonal Antibodies

MEK1/2 antibody

SKU : BHA10805105

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Mfr.No.	FNab05113
Background	The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
Categories	Primary Antibodies
Clonality	polyclonal
Host	Rabbit
Immunogen	mitogen-activated protein kinase kinase 2
Isotype	IgG
Molecular Weight	53 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	ERK activator kinase 2, FLJ26075, MAP kinase kinase 2, MAP2K2, MAPK/ERK kinase 2, MAPKK 2, MAPKK2, MEK 2, MEK2, MKK2, PRKMK2

Uniprot	P36507
Gene Id	5605
Research Area	Immunology, Signal Transduction, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IF
Description	ELISA ; WB ; IF
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab05113.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10805105	FNab05113	100ug	$240		Add to Cart

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