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Home / Primary Antibodies / Polyclonal Antibodies

MDC1 antibody

SKU : BHA10805064

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Mfr.No.	FNab05072
Alternative Names	KIAA0170 ; NFBD1
Background	The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.
Host	Rabbit
Immunogen	mediator of DNA damage checkpoint 1
Isotype	IgG
Molecular Weight	270 kDa
Reactivity	Human
Regulatory	RUO
Synonyms	KIAA0170, NFBD1

Uniprot	Q14676
Gene Id	9656
Research Area	Epigenetics, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC, IF
Description	ELISA ; IHC ; IF
Tested Application	WB: 1:500 - 1:2000; IHC: 1:100 - 1:200

Manual	FNab05072.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10805064	FNab05072	100ug	$280		Add to Cart

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