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Home / Primary Antibodies / Polyclonal Antibodies

MAVS; VISA antibody

SKU : BHA10805024

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Mfr.No.	FNab05032
Background	Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES(CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.It can undergoe phosphorylation on multiple sites and ubiquitination, which may together cause the molecular weight migrate to about 70 kDa despite the predicated 57 kDa.
Categories	Primary Antibodies
Clonality	polyclonal
Host	Rabbit
Immunogen	mitochondrial antiviral signaling protein
Isotype	IgG
Molecular Weight	70 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	CARD adapter inducing interferon beta,Interferon beta promoter stimulator protein 1,Cardif,Putative NF-kappa-B-activating protein 031N,Virus-induced-signaling adapter

Uniprot	Q7Z434
Research Area	Immunology, Signal Transduction

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IF, IP, IHC
Description	ELISA ; WB ; IF ; IP ; IHC
Tested Application	WB: 1:1000-1:4000; IP: 1:500-1:2000; IHC: 1:100-1:500; IF: 1:10-1:100

Manual	FNab05032.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10805024	FNab05032	100ug	$280		Add to Cart

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