Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.
Categories
Primary Antibodies
Clonality
monoclonal
Description
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore- spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.
Host
Mouse
Immunogen
MAD2 mitotic arrest deficient-like 1(yeast)
Isotype
IgG2a
Molecular Weight
25-30 kDa
Reactivity
Human
Regulatory
RUO
Synonyms
HSMAD2, MAD2, MAD2 like protein 1, MAD2L1
Uniprot
Q13257
Gene Id
4085
Clone No
8G6
Research Area
Cell Division and Proliferation
Form
liquid
Format
liquid
Purification
Protein A+G purification
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)