E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic(EGF receptors) and exocytic(HIV-1 viral proteins) cargos(PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens(PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation(xenophagy)(PubMed:23245322, PubMed:25484098).
Categories
Primary Antibodies
Clonality
polyclonal
Description
E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos (PubMed:15256501). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (PubMed:23245322). Localizes to several intracellular bacterial pathogens and generates the bacteria- associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (PubMed:23245322, PubMed:25484098).
Host
Rabbit
Immunogen
leucine rich repeat and sterile alpha motif containing 1
Isotype
IgG
Molecular Weight
84 kDa
Reactivity
Human, Mouse
Regulatory
RUO
Synonyms
TAL
Uniprot
Q6UWE0
Gene Id
90678
Research Area
Epigenetics, Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)