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Home / Primary Antibodies / Polyclonal Antibodies

LEF1 antibody

SKU : BHA10810550

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Mfr.No.	FNab10763
Background	Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1(By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.
Clonality	polyclonal
Host	Rabbit
Immunogen	lymphoid enhancer-binding factor 1
Immunogen Region	lymphoid enhancer-binding factor 1
Isotype	IgG
Molecular Weight	45-50 kDa
Reactivity	Human, Rat
Recommended Dilution	WB: 1:500-1:2000

Uniprot	Q9UJU2

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:500-1:2000

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10763.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10810550	FNab10763	100ug	$240		Add to Cart

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