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Home / Primary Antibodies / Polyclonal Antibodies

LDLR antibody

SKU : BHA10804734

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Mfr.No.	FNab04742
Background	LDLR (low density lipoprotein receptor) is a member of the LDL receptor gene family and is involved in receptor-mediated endocytosis of specific ligands. The LDLR is a cell surface glycoprotein that scavenges LDL from the blood and regulates plasma LDL cholesterol. The cytoplasmic domain of the LDL receptor is necessary for the receptor to cluster in coated pits, which promotes the rapid endocytosis of bound LDL. The protein is highly glycosylated through N- and O-linkages and thus migrates at 100 to 160 kDa bands on SDS-PAGE.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins (PubMed:10535997, PubMed:12615904). Acts as a receptor for vesicular stomatitis virus (PubMed:23589850). In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells (PubMed:11100124).
Host	Rabbit
Immunogen	low density lipoprotein receptor
Isotype	IgG
Molecular Weight	150-160 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	FH, FHC, LDL receptor, LDLR

Uniprot	P01130
Gene Id	3949
Research Area	Developmental biology, Cardiovascular, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IP
Description	ELISA ; WB ; IHC ; IP
Tested Application	WB: 1:500-1:1000; IHC: 1:50-1:500; IF: 1:50-1:500

Manual	FNab04742.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10804734	FNab04742	100ug	$260		Add to Cart

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