LDLR (low density lipoprotein receptor) is a member of the LDL receptor gene family and is involved in receptor-mediated endocytosis of specific ligands. The LDLR is a cell surface glycoprotein that scavenges LDL from the blood and regulates plasma LDL cholesterol. The cytoplasmic domain of the LDL receptor is necessary for the receptor to cluster in coated pits, which promotes the rapid endocytosis of bound LDL. The protein is highly glycosylated through N- and O-linkages and thus migrates at 100 to 160 kDa bands on SDS-PAGE.
Clonality
polyclonal
Host
Rabbit
Immunogen
low density lipoprotein receptor
Immunogen Region
low density lipoprotein receptor
Isotype
IgG
Molecular Weight
100-160 kDa
Reactivity
Human
Recommended Dilution
WB: 1:500-1:2000
Synonyms
FH, FHC, LDL receptor, LDLR
Uniprot
P01130
Gene Id
3949
Research Area
Developmental biology, Cardiovascular, Metabolism
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500-1:2000
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10870.pdf" target="_blank">Data Sheet</ a>