Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. This protein is not suitable for samples where the nuclear envelope has been removed.
Categories
Primary Antibodies
Clonality
monoclonal
Host
Mouse
Immunogen
lamin B1
Isotype
IgG2a
Molecular Weight
66kd
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
ADLD, lamin B1, LMN, LMN2, LMNB, LMNB1
Uniprot
P20700
Clone No
4A4
Research Area
Developmental biology, Stem Cells
Form
liquid
Format
liquid
Purification
Protein A+G purification
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)