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Home / Primary Antibodies / Polyclonal Antibodies

KEAP1 antibody

SKU : BHA10804508

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Mfr.No.	FNab04516
Alternative Names	INRF2 ; KIAA0132 ; KLHL19
Background	This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Host	Rabbit
Immunogen	kelch-like ECH-associated protein 1
Isotype	IgG
Molecular Weight	55-80 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	Cytosolic inhibitor of Nrf2, INrf2, KEAP1, Kelch like protein 19, KIAA0132, KLHL19

Uniprot	Q14145
Gene Id	9817
Research Area	Cancer, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC, IP, WB
Description	ELISA ; IHC ; IP ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Manual	FNab04516.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10804508	FNab04516	100ug	$240		Add to Cart

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