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Home / Primary Antibodies / Polyclonal Antibodies

KDM4A antibody

SKU : BHA10804504

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Mfr.No.	FNab04512
Alternative Names	JHDM3A ; JMJD2 ; JMJD2A ; KIAA0677
Background	This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.
Host	Rabbit
Immunogen	lysine (K)-specific demethylase 4A
Isotype	IgG
Molecular Weight	150 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	JHDM3A, JMJD2, JMJD2A, KIAA0677

Uniprot	O75164
Gene Id	9682
Research Area	Epigenetics, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab04512.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10804504	FNab04512	100ug	$280		Add to Cart

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