Forms a voltage-independent potassium channel that is activated by intracellular calcium(PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin(PubMed:17157250, PubMed:18796614).
Categories
Primary Antibodies
Clonality
monoclonal
Description
Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (PubMed:17157250, PubMed:18796614).
Host
Mouse
Immunogen
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
Isotype
IgG2a
Molecular Weight
48 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
IK1, IKCA1, KCA4, SK4
Uniprot
O15554
Gene Id
3783
Clone No
8A11
Research Area
Developmental biology, Neuroscience
Form
liquid
Format
liquid
Purification
Protein A+G purification
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)