This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.
Clonality
polyclonal
Host
Rabbit
Immunogen
insulin receptor substrate 1
Immunogen Region
insulin receptor substrate 1
Isotype
IgG
Molecular Weight
131 kDa
Reactivity
Human
Recommended Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Synonyms
HIRS 1, insulin receptor substrate 1, IRS 1, IRS1
Uniprot
P35568
Gene Id
3667
Research Area
Signal Transduction
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10261.pdf" target="_blank">Data Sheet</ a>