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Home / Primary Antibodies / Polyclonal Antibodies

IRF3 antibody

SKU : BHA10804381

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Mfr.No.	FNab04389
Background	This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
Host	Rabbit
Immunogen	interferon regulatory factor 3
Isotype	IgG
Molecular Weight	56 kDa
Reactivity	Human
Regulatory	RUO
Synonyms	IIAE7

Uniprot	Q14653
Gene Id	3661
Research Area	Epigenetics, Signal Transduction, Metabolism, Cancer, Immunology

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IF, IP, FC
Description	ELISA ; WB ; IHC ; IF ; IP ; FC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; ChIP : 1:20 - 1:100

Manual	FNab04389.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10804381	FNab04389	100ug	$260		Add to Cart

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