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Home / Primary Antibodies / Polyclonal Antibodies

IRF2 antibody

SKU : BHA10804378

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Mfr.No.	FNab04386
Background	IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
Host	Rabbit
Immunogen	interferon regulatory factor 2
Isotype	IgG
Molecular Weight	42 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	IRF-2

Uniprot	P14316
Gene Id	3660
Research Area	Epigenetics, Cancer, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IP
Description	ELISA ; WB ; IHC ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100

Manual	FNab04386.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10804378	FNab04386	100ug	$240		Add to Cart

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