Insulin is a peptide hormone, produced by beta cells of the pancreas, and is central to regulating carbohydrate and fat metabolism in the body. It participates in glucose utilization, protein synthesis and in the formation and storage of neutral lipids. Insulin is synthesized as a precursor molecule, proinsulin, which is processed prior to secretion. A-and B-peptides are joined together by a disulfide bond to form insulin, while the central portion of the precursor molecule is cleaved and released as the C-peptide. Defects in insulin results in type 1 diabetes mellitus. Insulin may also exist 36 kDa form corresponding to the hexameric insulin form.
Categories
Primary Antibodies
Clonality
monoclonal
Host
Mouse
Immunogen
insulin
Isotype
IgG2a
Reactivity
Human, Mouse
Regulatory
RUO
Synonyms
ILPR, INS, insulin, IRDN
Uniprot
P01308
Gene Id
3630
Clone No
0H2
Research Area
Signal Transduction, Metabolism, Immunology, Cancer, Stem Cells
Form
liquid
Format
liquid
Purification
Protein A+G purification
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)