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Home / Primary Antibodies / Polyclonal Antibodies

IL1 beta antibody

SKU : BHA10804203

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Mfr.No.	FNab04209
Alternative Names	IL1beta ; Catabolin ; IL1 ; IL1beta ; IL1BETA ; IL1B ; IL1beta ; IL1F2 ; IL-1β ; Interleukin1beta ; interleukin1
Background	The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Interleukin-1, produced mainly by blood monocytes, mediates the panoply of host reactions collectively known as acute phase response. It is identical to endogenous pyrogen. The multiple biologic activities that define IL1 are properties of a 15- to 18-kD protein that is derived from a 30- to 35-kD precursor. Interleukin 1β (IL-1B) is a member of the interleukin 1 cytokine family. It is a pro-inflammatory cytokine against infection, playing an important role in the pathogenesis of cancers. It signals through various adaptor proteins and kinases that lead to activation of numerous downstream targets. The expression level of IL-1B is very low.
Host	Rabbit
Immunogen	interleukin 1, beta
Isotype	IgG
Molecular Weight	17,35-40 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	IL1 beta, Catabolin, IL 1, IL 1 beta, IL1 BETA, IL1B, IL1beta, IL1F2, IL-1beta, Interleukin 1 beta, interleukin 1, beta

Uniprot	P01584
Gene Id	3553
Research Area	Immunology, Cardiovascular, Signal Transduction, Neuroscience
Weight	40kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IHC, IF, WB

Description

ELISA ; IHC ; IF ; WB

Dilution

WB	1:200-1:1000
IHC	1:20-1:200
IF	1:20-1:200

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab04209.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10804203	FNab04209	100ug	$240		Add to Cart

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