Participates in at least several B-cell activation processes as well as of other cell types(PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE(CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages(By similarity).
Categories
Primary Antibodies
Clonality
monoclonal
Host
Mouse
Immunogen
interleukin 4
Isotype
IgG2a
Molecular Weight
18 kDa
Reactivity
Human, Rat
Regulatory
RUO
Synonyms
B cell stimulatory factor 1, Binetrakin, BSF 1, BSF1, IL 4, IL4, IL-4, interleukin 4, PS1TP5BP1
Uniprot
P05112
Clone No
5A0
Research Area
Immunology, Cardiovascular, Signal Transduction
Form
liquid
Format
liquid
Purification
Protein A+G purification
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)