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Home / Primary Antibodies / Monoclonal Antibodies

IL-17 antibody

SKU : BHA10804218

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Mfr.No.	FNab04225
Background	IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2(PTGS2/COX-2), as well as enhance the production of nitric oxide(NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.
Categories	Primary Antibodies
Clonality	monoclonal
Host	Mouse
Immunogen	interleukin 17A
Isotype	IgG1
Molecular Weight	18 kDa
Reactivity	Human
Regulatory	RUO
Synonyms	CTLA 8, CTLA8, IL 17, IL 17A, IL17, IL-17, IL17A, interleukin 17A

Uniprot	Q16552
Gene Id	3605
Clone No	5E2
Research Area	Immunology, Cardiovascular, Signal Transduction

Form	liquid
Format	liquid
Purification	Protein A+G purification
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, FC
Description	ELISA ; WB ; FC
Tested Application	WB: 1:500-1:1000

Manual	FNab04225.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10804218	FNab04225	100ug	$260		Add to Cart

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