This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.
Clonality
polyclonal
Host
Rabbit
Immunogen
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Immunogen Region
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Isotype
IgG
Molecular Weight
40-55 kDa
Reactivity
Human
Recommended Dilution
WB: 1:500 - 1:2000
Synonyms
FIP3, NEMO
Uniprot
Q9Y6K9
Gene Id
8517
Research Area
Immunology, Cardiovascular, Metabolism, Signal Transduction
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500 - 1:2000
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10324.pdf" target="_blank">Data Sheet</ a>