This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.
Categories
Primary Antibodies
Clonality
polyclonal
Host
Rabbit
Immunogen
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
Isotype
IgG
Molecular Weight
39 kDa
Reactivity
Human, Mouse, Rat, Pig
Regulatory
RUO
Synonyms
I kappa B alpha, IkappaBalpha, IkB alpha, IKBA, Ikbeta-alpha, MAD 3, MAD3, NF kappa B inhibitor alpha, NFKBI, NFKBIA
Uniprot
P25963
Gene Id
4792
Research Area
Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Immunology
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)