IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
Categories
Primary Antibodies
Clonality
polyclonal
Description
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
Host
Rabbit
Immunogen
insulin-like growth factor binding protein 3
Isotype
IgG
Molecular Weight
32kd
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
BP 53, IBP 3, IBP3, IGF binding protein 3, IGFBP 3, IGFBP3
Uniprot
P17936
Gene Id
3486
Research Area
Signal Transduction, Cardiovascular, Immunology, Cancer, Stem Cells
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)