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Home / Primary Antibodies / Polyclonal Antibodies

IGF2BP3 antibody

SKU : BHA10804167

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Mfr.No.	FNab04173
Alternative Names	IMP3 ; KOC1 ; VICKZ3
Background	The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes.
Categories	Primary Antibodies
Clonality	polyclonal
Description	RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta- actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.
Host	Rabbit
Immunogen	insulin-like growth factor 2 mRNA binding protein 3
Isotype	IgG
Molecular Weight	72 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	IMP3, KOC1, VICKZ3

Uniprot	O00425
Gene Id	10643
Research Area	Epigenetics, Cancer, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IF, IP
Description	ELISA ; WB ; IHC ; IF ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

Manual	FNab04173.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10804167	FNab04173	100ug	$260		Add to Cart

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